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    • Anti-hnRNP U Monoclonal Antibody
    產(chǎn)品名稱(chēng):

    Anti-hnRNP U Monoclonal Antibody

    產(chǎn)品品牌: SOLARBIO/索萊寶 價(jià)格:
    廠(chǎng)商性質(zhì): 生產(chǎn)廠(chǎng)家 產(chǎn)品時(shí)間: 2024-04-17
    Anti-hnRNP U Monoclonal Antibody(Cat:K000059M) can be used for WB analysis of hnRNP U expression in the tissue and cell lysates(Dilution: WB1:1000 ; Reacts with:Human).

    產(chǎn)品概述

    品牌SOLARBIO/索萊寶貨號K000059M
    規格50ul/100ul供貨周期現貨
    主要用途WB

     Anti-hnRNP U Monoclonal Antibody

    英文名稱(chēng)Mouse hnRNP U Monoclonal Antibody
    別名hnRNP U
    應用WB
    稀釋比例WB1:1000
    交叉反應Human
    蛋白分子量110kDa
    Gene ID3192
    保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
    儲存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 70% Glycerol.
    純化方法Affinity purification
    亞型IgG1
    免疫原Purified recombinant human hnRNP U protein fragments expressed in E.coli.
    性狀Lyophilized or Liquid
    Swiss ProtQ00839
    克隆號1B11-H2-B7
    克隆類(lèi)型Monoclonal Antibody
    來(lái)源Mouse
    背景資料This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

     

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